GATA6 IS A CRUCIAL REGULATOR OF SHH IN THE LIMB BUD.

In the limb bud, patterning along the anterior-posterior (A-P) axis is controlled by Sonic Hedgehog (Shh), a signaling molecule secreted by the "Zone of Polarizing Activity", an organizer tissue located in the posterior margin of the limb bud.We have found that the transcription factors GATA4 and GATA6, which are key regulators of cell identity, ar

Cardiovascular diseases are the main source of death and morbidity in developed and developing nations.Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of the